Adipose tissue insulin resistance due to loss of PI3K p110α leads to decreased energy expenditure and obesity
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Adipose tissue insulin resistance due to loss of PI3K p110α leads to decreased energy expenditure and obesity.
Adipose tissue is a highly insulin-responsive organ that contributes to metabolic regulation. Insulin resistance in the adipose tissue affects systemic lipid and glucose homeostasis. Phosphoinositide 3-kinase (PI3K) mediates downstream insulin signaling in adipose tissue, but its physiological role in vivo remains unclear. Using Cre recombinase driven by the aP2 promoter, we created mice that l...
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OBJECTIVE Interleukin (IL)-18 is associated with obesity, insulin resistance, and cardiovascular disease. The present study compared 1) IL-18 in adipocytes versus stromal vascular (SV) cells, 2) IL-18 in plasma and adipose tissue (AT) in obese versus lean subjects, and 3) IL-18 in plasma, AT, and skeletal muscle (SM) in obese subjects after weight loss. SUBJECTS AND METHODS At baseline, plasm...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Endocrinology and Metabolism
سال: 2014
ISSN: 0193-1849,1522-1555
DOI: 10.1152/ajpendo.00625.2013